New Blood Test Helps Patients With Advanced Breast Cancer Cope With The Unknown

The CellSearch test is the first for counting circulating tumor cells (CTCs) in patients with advanced breast cancer to predict survival. CTCs are cancer cells that have detached from a solid tumor and entered the bloodstream. Developed by Immunicon Corporation of Huntingdon Valley, Pa. and exclusively marketed by Veridex LLC, a Johnson & Johnson company, this test is used to capture, count and characterize CTCs in a sample of blood and can suggest to an oncologist whether a treatment is working. Clinical studies reported in the New England Journal of Medicine and the Journal of Clinical Oncology have shown that five or more CTCs in a 7.5 ml blood sample is an indicator of decreased overall survival.

Why is this so important for patients with metastatic breast cancer? "Patients can learn the results of their treatment sooner rather than later," said Byron Hewett, President and CEO of Immunicon Corporation. "Traditional imaging scans can only be done every three to six months, during which time patients can become anxious, wondering if their cancer has spread or whether they are in remission. Oncologists can use this test to help determine a patient's status based on CTC count within three to four weeks after therapy. A CTC count of five or more is predictive of shorter progression-free survival and overall survival."

Mindy's oncologist, Dr. John Nemunaitis, Executive Medical Director at the Mary Crowley Medical Research Center in Dallas, Texas, recently used the CellSearch test to scan for CTCs. The numbers were high enough that he decided to order a PET scan, which showed several areas of cancer in Mindy's body. Before beginning experimental therapy at Mary Crowley, Mindy received four months of more chemotherapy along with Herceptin®, hoping this would reduce the tumors. Tests indicated that the tumors did not respond to the chemotherapy, so she began a clinical trial at Mary Crowley.

"I believe in my heart of hearts that had I waited and continued with the conventional method, I would not be alive," said Mindy. "I believe that this particular test has given me a chance to fight this disease with the many new treatments coming out and I hope it has saved my life."

For more information on the CellSearch test and circulating tumor cells, visit www.immuni con.com or www.veridex.com.

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