Phendimetrazine: Effectual Weight Loss, No Longer A Dream Phendimetrazine can be simply understood as an anorexigenic or anorectic drug. Phendimetrazine works by stimulating the central nervous system, which thereby enhances your heart rate and blood pressure resulting in lessening of your normal appetite. Phendimetrazine is employed as a short-term add-on to proper diet and exercise in the effectual treatment of obesity.