Menopause Treatment And Prevention Menopause is the physiological cessation of menstrual cycles associated with advancing age in women. Menopause is defined as absence of menstrual periods for 12 months. The menopausal transition starts with varying menstrual cycle length and ends with the final menstrual period. Perimenopause means "around the time of menopause." It is not officially a medical term, but is sometimes used to explain certain aspects of the menopause transition in lay terms. Many women experience a variety of symptoms as a result of the hormonal changes associated with the transition through menopause. Postmenopause is the entire period of time that comes after the last menstrual period. The menopause is sometimes referred to as change of life or climacteric.